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Blood glucose (A), lactate (B), ketones (week 12) (C), and plasma glucose (week 12) (D) levels in non-diabetic control rats and in diabetic rats treated with vehicle, metformin, canagliflozin, metformin + canagliflozin, or quercetin for a period of 12 weeks. Blood glucose test range: 20–600 mg/dL. Data are presented as mean ± SEM. * p < 0.05 vs. vehicle-treated diabetic rats, # p < 0.05 vs. non-diabetic control rats with normal renal function and ° p < 0.05 vs. week 0.
