Table 3.
Outcome for patients hospitalised with plasma sodium < 125 mmol/L, overall and by group.
| Overall (n = 263) | D-Group (n = 172) | N-Group (n = 91) | p-Value | |
|---|---|---|---|---|
| Hyponatremia as main diagnosis, n (%) | 43 (16.3) | 37 (14.1) | 6 (2.3) | 0.007 |
| Hyponatremia not mentioned in discharge report, n (%) | 24 (9.1) | 8 (3.0) | 16 (6.1) | 0.001 |
| No treatment received for hyponatremia, n (%) | 36 (13.7) | 14 (8.1) | 22 (24.2) | <0.001 |
| Complications, n (%) | 47 (17.9) | 31 (18.0) | 16 (17.6) | 0.929 |
| Further decline in plasma sodium, n (%) | 27 (10.3) | 16 (9.3) | 11 (12.1) | 0.479 |
| Overcorrection 1, n (%) | 18 (6.8) | 14 (8.1) | 4 (4.4) | 0.253 |
| Subsequent transfer to ICU/IMC, n (%) | 2 (0.8) | 1 (0.6) | 1 (1.1) | 0.646 |
| ODS (osmotic demyelination syndrome), n (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | N/A |
| Brain stem herniation, n (%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | N/A |
| P-Na < 125 mmol/L prior to discharge, n (%) | 22 (8.4) | 14 (8.1) | 8 (8.8) | 0.126 |
| Length of hospital stay (days), median, IQR | 9, 5–14 | 9, 6–14 | 8, 4–14 | 0.151 |
| Discharge destination | ||||
| Home, n (%) | 186 (70.7) | 126 (73.3) | 60 (65.9) | 0.214 |
| First ever in nursing home, n (%) | 1 (0.4) | 0 (0.0) | 1 (1.1) | 0.168 |
| Rehabilitation clinic, n (%) | 48 (18.3) | 31 (18.0) | 17 (18.7) | 0.895 |
| Other hospital, n (%) | 17 (6.5) | 10 (5.8) | 7 (7.7) | 0.556 |
| Rehospitalisation within 12 months 2, n (%) | 106 (42.1) | 71 (42.5) | 35 (41.2) | 0.839 |
| Hyponatremia at rehospitalisation, n (%) | 72 (67.9) | 52 (73.2) | 20 (57.1) | 0.095 |
| Hyponatremia main diagnosis at rehospitalisation, n (%) | 10 (13.9) | 6 (8.5) | 4 (11.4) | 0.352 |
| All cause death within 12 months, n (%) | 41 (15.6) | 26 (12.8) | 15 (16.5) | 0.876 |
| All cause in-hospital death, n (%) | 11 (4.2) | 5 (2.9) | 6 (6.6) | 0.155 |
1 defined as sodium correction rate >10 mmol/L in 24 h or >18 mmol/L in 48 h after diagnosis, ICU = intensive care unit, IMC = intermediate care unit, 2 11 patients died in index hospitalisation and could not be rehospitalised, P-Na = plasma sodium, D-Group: minimum diagnostic workup complete, N-Group: incomplete minimum diagnostic workup.