Table 2.
Performance of four non-culture-based methods when testing cerebrospinal fluid samples from patients with meningeal sporotrichosis and with other suspected central nervous system diseases.
| Parameter | Nested PCR | qPCR | IgG ELISA | IgM ELISA |
|---|---|---|---|---|
| Sensitivity | 92.9% (66.1–99.8) |
78.6% (49.2–95.3) |
92.9% (66.1–99.8) |
92.9% (66.1–99.8) |
| Specificity | 75.0% (42.8–94.5) |
91.7% (61.5–99.8) |
100% (73.5–100) |
100% (73.5–100) |
| Accuracy | 84.6% (65.1–95.6) |
84.6% (65.1–95.6) |
96.2% (80.4–99.9) |
96.2% (80.4–99.9) |
| Positive likelihood ratio | 3.71 (1.38–10.00) |
9.43 (1.42–62.81) |
∞ | ∞ |
| Negative likelihood ratio | 0.10 (0.01–0.65) |
0.23 (0.08–0.65) |
0.07 (0.01–0.47) |
0.07 (0.01–0.47) |
PCR: polymerase chain reaction. qPCR: quantitative PCR. ELISA: enzyme-linked immunosorbent assay. The 95% confidence interval is presented within the parenthesis. ∞: infinity.