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. 2023 May 26;8:10. doi: 10.1186/s41181-023-00196-1

Table 2.

Comparison of reaction conditions of Charité (synthesis no.1–5) with Iori et al.

Charité Iori et al. (Iori et al. 2017)
Reaction temperature (°C) 95 90
Reaction time (min) 30 30
RCY (%) 93.4 ± 3.9 83.1 ± 5.7
RCP (%) radio-HPLC 99.7 ± 0.2 99.3
RCP (%) TLC 99.7 ± 0.3 98.4
amount of DOTA-TOC (µg/GBq) 10.0–17.0 11