Table 1.
List of the top 15 hub genes after hyperthermia treatment in the PPI network, which were calculated by method MCC.
| No. | Gene | Description | Style | Degree | log2FC | P value |
|---|---|---|---|---|---|---|
| 1 | TNF | Tumor necrosis factor | Up | 96 | 6.327454491 | 1.36E-13 |
| 2 | FOS | Fos proto-oncogene, AP − 1 transcription factor subunit | Up | 53 | 6.464266453 | 2.55E-75 |
| 3 | CXCL10 | C-X-C motif chemokine ligand 10 | Up | 49 | 5.330646742 | 1.01E-06 |
| 4 | CCL5 | C-C motif chemokine ligand 5 | Up | 44 | 6.062745054 | 2.78E-07 |
| 5 | EGR1 | Early growth response 1 | Up | 37 | 7.263225519 | 4.24E-22 |
| 6 | IL31 | Interleukin 31 | Up | 30 | 6.100491976 | 3.35E-05 |
| 7 | FOSB | FosB proto-oncogene, AP − 1 transcription factor subunit | Up | 26 | 8.553101371 | 5.63E-56 |
| 8 | HSPA1A | Heat shock protein family A (Hsp70) member 1 A | Up | 26 | 8.00080639 | 1.00E-54 |
| 9 | HSPB8 | Heat shock protein family B (small) member 8 | Up | 25 | 10.55905491 | 1.34E-11 |
| 10 | CRYAB | Crystallin alpha B | Up | 25 | 10.5030895 | 1.79E-146 |
| 11 | HSPA6 | Heat shock protein family A (Hsp70) member 6 | Up | 24 | 12.34220903 | 4.54E-45 |
| 12 | ARC | Activity regulated cytoskeleton associated protein | Up | 24 | 8.836556832 | 5.51E-157 |
| 13 | IL17F | Interleukin 17 F | Up | 24 | 5.75885765 | 0.00048 |
| 14 | HSPA1B | Heat shock protein family A (Hsp70) member 1B | Up | 23 | 6.946689163 | 3.84E-45 |
| 15 | EGR3 | Early growth response 3 | Up | 23 | 6.423293135 | 1.78E-10 |