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. 2023 May 26;6:563. doi: 10.1038/s42003-023-04954-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Scheme of the approach used to determine gene-enhancer associations and enhancer-enhancer associations from SHARE-seq data. Enhancer-enhancer associations were calculated for pairs of enhancers significantly associated with genes; b Enhancer-enhancer association correlation distribution (N = 126,830). The inner plot denotes the percentage of significant associations (green colour, FDR < 5% and absolute correlation > 0.05); c Hi-C contacts (log distance-scaled, 5 kb resolution) per enhancer-enhancer correlation value (N = 126,830).