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. 2023 May 26;6:563. doi: 10.1038/s42003-023-04954-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Enhancer combinations observed in single cells for the ABHD4 example gene with three associated enhancers. All seven possible combinations between three enhancers are represented (y-axis), with colour intensity mapped to the number of cells in which the combinations are observed; b Percentage of enhancer combinations observed in at least one cell (y-axis) per number of enhancers significantly associated with the gene (x-axis). Grey dots and nearby values represent the mean. Sample sizes for each category are provided in the bottom of the plot; c Percentage of significantly associated enhancer-enhancer pairs (y-axis) per number of enhancers significantly associated with the gene (x-axis); d Percentage of genes in which enhancer-enhancer pairs are significantly associated (y-axis) per number of genes in which they were tested (x-axis). A total of 45,679 distinct enhancer-enhancer pairs were analysed. For all boxplots, the length of the box corresponds to the IQR with the centre line corresponding to the median, the upper and lower whiskers represent the largest or lowest value no further than 1.5 × IQR from the third and first quartile, respectively.