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. 2023 May 26;13:8572. doi: 10.1038/s41598-023-35080-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Data plots resulting from the analysis of the entire cohort. (A, C) Data plots resulting from the analysis of the entire cohort show a positive monotonic tendency between FD features (average size and percentage) and neovascular growth patterns, i.e., neovascular growth and the value of FD features moved in the same direction but not necessarily at a constant rate. (B, D) A monotonic relationship is better appreciated after binning FD features into uniform classes and plotting against the average neovascular growth (mean ± standard error of the mean) for each interval.