Table 2.
Flap perfusion parameters of the study population
| Variable | No | Yes | p value |
|---|---|---|---|
| Intraoperative measurement | |||
| AHTN | |||
| Blood flow (AU) | 74.8 (52.9) | 73.3 (50.0) | 0.988 |
| Hemoglobin concentration (AU) | 53.5 (18.5) | 51.5 (16.9) | 0.099 |
| Hemoglobin oxygen saturation (%) | 69.3 (29.8) | 67.8 (27.3) | 0.962 |
| DM | |||
| Blood flow (AU) | 74.5 (51.9) | 76.0 (52.4) | 0.926 |
| Hemoglobin concentration (AU) | 52.0 (19.9) | 54.5 (17.1) | 0.694 |
| Hemoglobin oxygen saturation (%) | 68.3 (29.0) | 71.3 (21.3) | 0.286 |
| ASVD | |||
| Blood flow (AU) | 75.5 (49.4) | 63.3 (73.9) | 0.058 |
| Hemoglobin concentration (AU) | 52.8 (19.5) | 51.5 (17.3) | 0.258 |
| Hemoglobin oxygen saturation (%) | 69.5 (27.0) | 63.3 (28.1) | 0.046* |
| AHTN/DM/ASVD | |||
| Blood flow (AU) | 76.0 (51.8) | 71.5 (53.3) | 0.160 |
| Hemoglobin concentration (AU) | 53.5 (18.5) | 52.0 (17.5) | 0.244 |
| Hemoglobin oxygen saturation (%) | 70.0 (28.8) | 68.0 (29.0) | 0.691 |
| Postoperative measurement | |||
| AHTN | |||
| Blood flow (AU) | 81.0 (54.5) | 85.3 (61.6) | 0.924 |
| Hemoglobin concentration (AU) | 46.0 (19.9) | 48.5 (17.9) | 0.224 |
| Hemoglobin oxygen saturation (%) | 61.8 (26.4) | 60.0 (27.3) | 0.635 |
| DM | |||
| Blood flow (AU) | 80.8 (57.1) | 85.0 (52.8) | 0.396 |
| Hemoglobin concentration (AU) | 47.5 (18.5) | 43.5 (16.4) | 0.028** |
| Hemoglobin oxygen saturation (%) | 60.5 (26.5) | 61.3 (27.1) | 0.969 |
| ASVD | |||
| Blood flow (AU) | 85.0 (55.3) | 67.5 (54.0) | 0.036*** |
| Hemoglobin concentration (AU) | 47.0 (19.1) | 43.8 (18.6) | 0.190 |
| Hemoglobin oxygen saturation (%) | 61.0 (26.1) | 57.5 (28.5) | 0.339 |
| AHTN/DM/ASVD | |||
| Blood flow (AU) | 83.0 (54.5) | 81.0 (58.0) | 0.213 |
| Hemoglobin concentration (AU) | 47.0 (21.0) | 46.5 (18.5) | 0.751 |
| Hemoglobin oxygen saturation (%) | 62.0 (26.0) | 60.5 (27.5) | 0.682 |
Parameters are indicated as median (with interquartile range) for intraoperative and postoperative measurement (separately described for patients without and with AHTN, for patients without and with DM, for patients without and with ASVD, and for patients without and with arterial hypertension, diabetes mellitus and or atherosclerotic vascular disease (AHTN/DM/ASVD)); p values corresponding to testing for differences between groups with Mann–Whitney test; significant p values are bold (*p = 0.094 upon adjustment for sex, age, ASA (1 + 2 vs. 3 + 4), prior neck irradiation, flap type (RFFF vs. ALTF vs. FFF), flap location (intraoral vs. extraoral), mean arterial blood pressure (mmHg), and administered catecholamine dose (µg/min/kg) in multiple linear regression analysis; **p = 0.060 upon adjustment for age, BMI (≤ 25 vs. > 25), flap type (RFFF vs. ALTF vs. FFF), flap location (intraoral vs. extraoral), mean arterial blood pressure (mmHg), and administered catecholamine dose (µg/min per kg) in multiple linear regression analysis; ***p = 0.311 upon adjustment for sex, age, ASA (1 + 2 vs. 3 + 4), prior neck irradiation, flap type (RFFF vs. ALTF vs. FFF), flap location (intraoral vs. extraoral), mean arterial blood pressure (mmHg), and administered catecholamine dose (µg/min per kg) in multiple linear regression analysis
AHTN arterial hypertension, DM diabetes mellitus, ASVD atherosclerotic vascular disease, AU arbitrary units, RFFF radial free forearm flap, ALTF anterolateral thigh flap, FFF fibula free flap