Table 1.
Summary of studies included in the systematic review and meta-analysis
| Author | Year | Country | Design | Patients with iPCAO (n) | Occlusion site (n) | Endovascular treatment | Only best medical treatment | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients (n) | Age (years) | Sex (M/F) | Baseline NIHSS | IVT | Endovascular treatment method | Patients (n) |
Age (years) | Sex (M/F) | Baseline NIHSS | IVT | ||||||
| Brouwer et al. [9] | 2022 | Netherlands | Multicenter prospective cohort | 20 | P1 (n = 17), P2 (n = 2), P3 (n = 1) | 20 | 72 (±4.5) | 7/13 | 13 (5–21) | 12 (60%) | Stent retriever; aspiration thrombectomy; intra-arterial thrombolysis | – | – | – | – | – |
| Baik et al. [10] | 2022 | Republic of Korea | Multicenter retrospective cohort | 48 | P1 (n = 17), P2 (n = 31) | 48 | 69.6 (±15.9) | 34/14 | 9 (6–14) | 18 (37.5%) | Stent-retriever; aspiration thrombectomy; intra-arterial thrombolysis | – | – | – | – | – |
| Fischer et al. [11] | 2022 | Germany | Multicenter retrospective cohort | 8 | P2 (n = 8) | 8 | NR | NR | NR | NR | Stent retriever | – | – | – | – | – |
| Baig et al. [12] | 2021 | USA | Single-center retrospective cohort | 21 | P1 (n = 13), P2 (n = 8) | 21 | 71.2 (±10.2) | 9/12 | 9 (5–15) | 10 (47.6%) | Stent-retriever; aspiration thrombectomy | – | – | – | – | – |
| Cunha et al. [13] | 2021 | Portugal | Single-center retrospective cohort | 38 | P1 (n = 19), P2 (n = 16), P3 (n = 3) | 25 |
79.3 (±2.4) |
16/9 |
10 (6.0–14.5) |
14 (56%) | Stent retriever; aspiration thrombectomy; intra-arterial thrombolysis | 13 | 75.3 (±3.93) | 7/6 | 8 (5.5–10.0) | 13 (100%) |
| Altenbernd et al. [14] | 2021 | Germany | Single-center retrospective cohort | 79 | P1 (n = 60), P2 (n = 19) | 79 | 72.8 (±11.6) | 35/44 | 12 (4–15) | 43 (54%) | Stent retriever; aspiration thrombectomy | – | – | – | – | – |
| Herweh et al. [15] | 2021 | Germany, USA, Taiwan | Multicenter retrospective cohort | 130 | P1 (n = 62), distal to P1 (n = 68) | 23 | 70 (±13.3) | 14/9 | 9 (1–20)a | 5 (22%) | Mechanical thrombectomy | 107 | 74 (±13.1) | 56/51 | 7 (1–38)a | 44 (41%) |
| Meyer et al. [16] | 2021 | Germany, France, USA, Singapore, Sweden, Spain, Switzerland | Multicenter case-control study | 243 | P2 (n = 199), P3 (n = 44) | 143 | 72.66 (±14.1) | 79/64 | 7 (4–11) | 57 (40%) | Stent retriever; aspiration thrombectomy; intra-arterial thrombolysis | 92 | 72.2 (±14.3) | 42/50 | 5 (2–10) | 53 (58%) |
| Miszczuk et al. [17] | 2021 | Germany | Multicenter retrospective cohort | 17 | P2 (n = 14), P3 (n = 3) | 17 | 74 (58–81) | NR | 10 (5–14) | 8 (47%) | Stent retriever; aspiration thrombectomy | – | – | – | – | – |
| Clarençon et al. [18] | 2020 | France, Switzerland, USA, Czech Republic, Spain | Multicenter retrospective cohort | 22 | P1 (n = 17), P2 (n = 5) | 22 | 66.2 (±14.3) | 12/10 | 14 (8–16) | 11 (50%) | Stent retriever | – | – | – | – | – |
| Memon et al. [19] | 2020 | USA | Single-center retrospective cohort | 15 | P1 (n = 12), P1/P2 junction (n = 3) | 15 | 64 (±17) | 6/9 | 9 (5–15) | 7 (46%) | Stent retriever | – | – | – | – | – |
| Strambo et al. [20] | 2020 | Switzerland | Single-center retrospective cohort | 106 | P1 (n = 34), P2 (n = 72) | 21 |
71 (64–78.2) |
8/13 | 7 (5–8.3) | 13 (62%) | Stent retriever; aspiration thrombectomy; intra-arterial thrombolysis | 85 | 76.6 (68.3–83.8) | 48/37 | 7 (4–12) | 34 (40%) |
| Grossberg et al. [21] | 2018 | USA | Single-center retrospective cohort | 3 | NR | 3 | 66 (±26.5) | 3/0 | 14 (8–22) | 2 (67%) | Stent-retriever; aspiration thrombectomy | – | – | – | – | – |
| Premat et al. [22] | 2018 | France | Single-center retrospective cohort | 7 |
P1 (n = 3), P2 (n = 2), P3 (n = 2) |
7 | NR | NR | 7 (5–28) | NR | Stent-retriever; aspiration thrombectomy | – | – | – | – | – |
| Meier et al. [23] | 2011 | Switzerland | Single-center prospective cohort | 18 |
P1(n = 7), P2 (n = 10), P3 (n = 1) |
9 | 66 (±11.6) | 5/4 | 9 (6–16) | 0 | Intra-arterial thrombolysis; mechanical thrombectomy | 9 | 58 (±16.2) | 7/2 | 4 (3–6) | 9 (100%) |
Values are presented as n (%), mean (± SD) or median (IQR)
NIHSS National Institutes of Health Stroke Scale, IVT intravenous thrombolysis, M male, F female, NR not reported, iPCAO isolated posterior cerebral artery occlusion
aMedian (range)