Fig. 1.
NODDI and DTI metric differences in the microstructure of the white matter. Red indicates significantly increased metrics in the T2DM group compared to the HC group with (1 − PFWE) > 0.95; blue indicates significantly decreased metrics in the T2DM group compared to the HC group with (1 − PFWE) > 0.95; z values indicate MNI coordinates of the cross-section slice; arrowheads highlight regions with abnormal ODI. The “Z” represents the MNI coordinate of the cross-section slice. T2DM type 2 diabetes mellitus, HC healthy controls, FWE familywise error, DTI diffusion tensor imaging, NODDI neurite orientation dispersion and density imaging, FA fractional anisotropy, AD axial diffusivity, ODI orientation dispersion index, ATR anterior thalamic radiation, CGC cingulum, CST corticospinal tract, FMI forceps minor, FMA forceps major, IFOF inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus, UNF uncinate fasciculus