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. 2023 Jan 10;7(11):2364–2374. doi: 10.1182/bloodadvances.2022008854

Figure 4.

Figure 4.

Coexpression of TIM-3 and PD-1 on CD4+T-cells in patients with CML and in HD. (A) PD-1−TIM-3+CD4+ T cells as a percentage of CD4+ T cells were significantly higher in both the patients in MolR group and those in TFR group than in healthy donors (HD). Furthermore, the HD had lower expression of TIM-3 than patients in the TFR group. (B) The absolute counts of PD-1−TIM-3+CD4+ T cells was higher in patients in the MolR group than those in the TFR group. (C) PD-1+TIM-3−CD4+ T cells as percentage of CD4+ T cells or (D) absolute counts of PD-1+TIM-3−CD4+ T cells were not different between the groups. (E) PD-1+TIM-3+CD4+ T cells as a percentage of CD4+ T cells was higher in the patients who experienced MolR than in those with sustained TFR and in HD. (F) Absolute counts of PD-1+TIM-3+CD4+ T cells were significantly higher in the MolR group compared with the TFR group. (G) Conversely, PD-1−TIM-3−CD4+ T cells were significantly lower in the MolR group compared with both the TFR and HD group. (H) There was no difference in the absolute counts of PD-1−TIM-3−CD4+ T cells. The Mann-Whitney test was used to compare 2 groups, whereas multiple comparisons were made using the Kruskal-Wallis test; alpha was set at 0.05 (adjusted for multiple comparisons).