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Activity profiles of top GPX4 inhibitors. Structure and activity profile of A) pranlukast sodium hydrate; B) lusutrombopag C) brilanestrant; D) simeprevir E) grazoprevir (MK-5172); F) paritaprevir; G) navitoclax; H) venetoclax; I) VU0661013. Data are normalized to DMSO and presented as mean ± s.d. of n = 3 replicates.
