Table 4.
Generalized Estimating Equation (GEE): expected values for different markers by time and degree of NAFLD severity.
| Glucose | Insulin | Homa-IR | Hb1Ac | |||||
|---|---|---|---|---|---|---|---|---|
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| Follow-up | ||||||||
| Baseline | 0.00 | 0.00 | 0.00 | 0.00 | ||||
| 3 month | −4.65 | −9.74; 0.44 | −2.39 * | −4.50; −0.28 | −0.59 | −1.28; 0.09 | −1.93 * | −3.59; −0.27 |
| 6 month | −3.74 | −9.05; 1.57 | −1.72 | −3.88; 0.44 | −0.39 | −1.09; 0.31 | −3.84 ** | −5.55; −2.13 |
| 9 month | −8.56 ** | −14.34; −2.77 | −0.91 | −3.38; 1.57 | −0.39 | −1.16; 0.39 | −4.80 ** | −6.68; −2.91 |
| 12 month | −8.54 ** | −15.15; −1.94 | −1.82 | −4.62; 0.99 | −0.72 | −1.57; 0.13 | −5.41 ** | −7.51; −3.32 |
| NAFLD | ||||||||
| Absent | 0.00 | 0.00 | 0.00 | 0.00 | ||||
| Mild | −3.47 | −9.73; 2.78 | 0.96 | −1.26; 3.17 | 0.23 | −0.44; 0.89 | −1.72 | −3.80; 0.36 |
| Moderate | −0.11 | −6.32; 6.09 | 2.39 | −0.02; 4.80 | 0.92 ** | 0.19; 1.66 | −1.14 | −3.23; 0.95 |
| Severe | 10.29 * | 1.89; 18.68 | 2.28 | −1.13; 5.69 | 1.35 * | 0.22; 2.47 | 0.32 | −2.46; 3.09 |
Adjusted for age, sex and BMI ** p < 0.001 * p < 0.05. Homa-IR: Homeostatic Model Assessment for Insulin Resistance; HbA1c: Glycosylated Haemoglobin; NAFLD: Non-Alcoholic Fatty Liver Disease.