Figure 4.

Crystal structures of (+)-BNM-III-170, TFH-070-A6, TFH-I-116-D-1, TFH-II-151, ZXC-I-090, ZXC-I-092, DL-I-101, and DL-I-102 derivatives in complex with a gp120_{CRF01_AE} LMHS or LMHT core_e. (+)-BNM-III-170, (S)-MCG-IV-210, and piperidine analogs within the Phe⁴³ cavity. (A) gp120 is shown as a surface with the β20-21 loop region and D³⁶⁸ colored pale yellow and green, respectively. (B) gp120 is shown as a ribbon with the β21-21 loop region colored yellow, and D³⁶⁸ and Ser/Thr³⁷⁵ are shown as green sticks or as a blue sphere. (C) Superimposition of the piperidine derivatives onto (+)-BNM-III-170 and (S)-MCG-IV-210.