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. 2023 May 17;15(5):1185. doi: 10.3390/v15051185

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Small CD4-mimetic neutralization of viral particles. Neutralization of VSV-G pseudovirus (A), HIV-1_CH58TF (B), HIV-1_JRFL (C), or HIV-1_AD8 (D) virus was performed with the indicated amounts of different compounds or the same volume of DMSO in TZM-bl cells. Luciferase activity (RLU—relative light units) was measured. Relative infectivity was calculated as the percentage of the value seen in the absence of compounds. Cell viability for TZM-bl ((E), left) or primary CD4+ T cells ((E), right) with different CD4mcs was measured using CellTiter-Glo One Solution assay for the quantitation of ATP presented in live cells. Data shown are the mean ± SD of at least three independent experiments.

Small CD4-mimetic neutralization of viral particles. Neutralization of VSV-G pseudovirus (A), HIV-1_CH58TF (B), HIV-1_JRFL (C), or HIV-1_AD8 (D) virus was performed with the indicated amounts of different compounds or the same volume of DMSO in TZM-bl cells. Luciferase activity (RLU—relative light units) was measured. Relative infectivity was calculated as the percentage of the value seen in the absence of compounds. Cell viability for TZM-bl ((E), left) or primary CD4+ T cells ((E), right) with different CD4mcs was measured using CellTiter-Glo One Solution assay for the quantitation of ATP presented in live cells. Data shown are the mean ± SD of at least three independent experiments.