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. 2023 May 12;59(5):938. doi: 10.3390/medicina59050938

Table 2.

Structural characteristics and differences of CD34 family proteins [3,14,19,20,21].

Structural Characteristics CD34 Endoglycan Podocalyxin
Mucin domain length 120 amino acids 350 amino acids 250 amino acids
Cysteine globular domains Three pairs Single pair Two pairs
Cysteine in juxtamembrane region Absent Unpaired—involved in its homodimerization Absent
N-Linked glycosylation sites Numerous Numerous Numerous
Extracellular effective size range (kDa) 90–170 90–170 90–170
Nonglycosylated N-terminal sequences Absent Present—high abundance of glutamic acid. Absent
C-terminal binding pattern Mildly modified—which has functional implications for intracellular ligand binding Similar to podocalyxin Similar to endoglycan