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. 2023 May 19;59(5):983. doi: 10.3390/medicina59050983

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Def^+/+ mice show different respiratory profile compared to their WT littermates. Alpha-defensin transgenic mice demonstrate lower respiratory quotient (A); overexpression of alpha-defensin does not change total energy expenditure (TEE; B), but significantly increases fat oxidation (C) and lowers carbohydrate oxidation (D). Method: Mice were monitored using the Promethion High-Definition Behavioral Phenotyping System (Sable Instruments, Inc., Las Vegas, NV, USA) over a 24 h period. Effective mass was calculated by power of 0.75. Data are mean ± SD from 4 mice per group. *** p < 0.001 vs. C57 WT, **** p < 0.0001 vs. C57 WT.