Figure 5.

Expression of interferons and inflammatory cytokines in mouse brains infected IC with CHIKV. Relative expression of Ifna4 (A), Ifnb1 (B), Ifng (C), Tnf (D), Il6 (E), and Il10 (F) in the brains of 4–6-week-old B6 mice following IC CHIKV infection was measured by qRT-PCR. Open symbols represent samples with one or both replicates below the assay limit of detection; dotted horizontal lines represent gene expression of mock-infected control brains; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001, Tukey’s multiple comparisons.