Figure 6.
Cartoon representation of different M1 family aminopeptidases: (A) pepN from Escherichia coli (PDB ID: 2dq6), (B) Plasmodium falciparum aminopeptidase N PfA-M1 (PDB ID: 3ebh), (C) human ERAP 1 (PDB ID: 3mdj), (D) human ERAP 2 (PDB ID: 3se6), (E) human leukotriene A4 hydrolase (PDB ID: 1hs6), (F) Saccharomyces cerevisiae leukotriene A4 hydrolase (PDB ID: 2xq0), (G) Thermoplasma acidophilum tricorn interacting factor F3 (PDB ID: 1z1w), (H) Colwellia psychrerythraea cold-active aminopeptidase (PDB ID: 3cia). Colors: alpha-helices (cyan), beta sheets (warm pink), and loops (salmon). The zinc atoms are shown as gray spheres highlighted in a yellow box.