Table 6.
Summary of the preliminary characterization of inhibitory activities against porcine APA, porcine APN, and human APN in TCA 2.5% treated crude extracts from marine invertebrates (screening in the period 2015–2019). Effect on 3LL and PC3 tumor cell viability (adapted from [98]). ND: not determined.
| Species | Phylum | IC50 vs. pAPA (µg/mL) | IC50 vs. pAPN (µg/ML) | IC50 vs. hAPN (µg/mL) | IC50 vs. 3LL Viability (µg/mL) | IC50 vs. PC3 Viability (µg/mL) |
|---|---|---|---|---|---|---|
| Cenchritis muricatus | Mollusca | ND | ND | 450.20 ± 77.40 | 214.00 ± 46.50 | 352.90 ± 65.00 |
| Nerita peloronta | Mollusca | 487 ± 11.03 | 287.03 ± 12.00 | 237.80 ± 20.90 | 273.30 ± 78.80 | 299.10 ± 31.70 |
| Nerita versicolor | Mollusca | 92.23 ± 12.34 | 132.11 ± 22.05 | 370.00 ± 50.00 | 358.80 ± 70.20 | 289.70 ± 39.70 |
| Lissodendoryx (Lissodendoryx) isodictyalis | Porifera | 659.87 ± 10.65 | 613.24 ± 10.76 | 11.70 ± 2.70 | <5.00 | <5.00 |
| Tripneustes ventricosus | Echinodermata | 11.03 ± 0.12 | 13.35 ± 3.91 | 25.00 ± 3.10 | 39.90 ± 2.00 | 77.00 ± 3.90 |
| Echinaster (Othilia) echinophorus | Echinodermata | 182.01 ± 67.12 | 112.55 ± 23.21 | 198.20 ± 27.20 | 265.70 ± 29.60 | 405.60 ± 50.40 |
| Isostichopus badionotus | Echinodermata | 1005.12 ± 293.32 | 11.08 ± 0.27 | 69.70 ± 10.00 | 57.10 ± 2.70 | 83.10 ± 3.00 |
| Stichodactyla helianthus | Cnidaria | 256.3 ± 10.00 | 136.56 ± 22.87 | 103.60 ± 20.60 | 110.80 ± 13.20 | 58.10 ± 7.50 |
| Bunodosoma granuliferum | Cnidaria | ND | 98.02 ± 18.05 | 567.60 ± 88.00 | 786.80 ± 37.10 | 711.30 ± 29.30 |
| Physalia physalis | Cnidaria | ND | 198.92 ± 10.76 | 123.10 ± 21.30 | 257.30 ± 6.70 | 234.50 ± 5.00 |
| Bestatin (positive control) | - | 25.50 ± 2.35 | 6.54 ± 0.82 | 6.70 ± 1.90 | 0.54 ± 0.01 | 3.15 ± 0.72 |
| Amastatin (positive control) | - | 75.45 ± 4.55 | 58.32 ± 3.34 | 63.45 ± 7.61 | ND | ND |