Table 1.
Mean ± SD of IFN-γ-induced metabolic pathways metabolites at baseline.
| Mean ± SD Healthy Age-Matched Control Group | Mean ± SD Study Population | p-Value (1) | Mean ± SD Female | Mean ± SD Male | p-Value (2) | |
|---|---|---|---|---|---|---|
| Neopterin (nmol/L) | 6.0 ± 1.6 | 7.3 ± 2.8 | 0.04 | 6.9 ± 2.7 | 7.0 ± 3.0 | n.s. |
| Tryptophan (μmol/L) | 68.4 ± 11.8 | 56.6 ± 9.7 | 0.005 | 55.6 ± 8.9 | 61.4 ± 9.5 | 0.01 |
| Kynurenine (μmol/L) | 1.8 ± 0.4 | 1.6 ± 0.4 | 0.03 | 1.5± 0.3 | 1.8 ± 0.3 | 0.04 |
| Kyn/Trp (μmol/mmol) | 27.2 ± 6.8 | 29.0 ± 6.4 | n.s. | 28.8 ± 6.9 | 29.8 ± 7.6 | n.s. |
| Tyrosine (μmol/L) | 87.8 ± 24.7 | 64.8 ± 16.4 | 0.004 | 62.0 ± 15.2 | 67.5 ± 13.1 | 0.03 |
| Phenylalanine (μmol/L) | 64.2 ± 10.6 | 81.0 ± 12.0 | <0.001 | 78.4 ± 12.3 | 79.2 ± 12.4 | n.s. |
| Phe/Tyr (μmol/μmol) | 0.8 ± 0.1 | 1.3 ± 0.2 | <0.001 | 1.3 ± 0.2 | 1.2 ± 0.2 | 0.03 |
(1) Significant differences between the healthy age-matched control group and study population. (2) Significant differences between females and males