Table 2.
Mean levels ± SD of IFN-γ-induced metabolic pathways metabolites after 6 months of treatment.
| Mean ± SD Female 3 Months | Mean ± SD Male 3 Months | p-Value (1) | Mean ± SD Female 6 Months | Mean ± SD Male 6 Months | p-Value (2) | |
|---|---|---|---|---|---|---|
| Neopterin (nmol/L) | 7.3 ± 2.8 | 7.6 ± 4.4 | n.s. | 9.7 ± 13.3 | 7.7 ± 3.6 | n.s. |
| Tryptophan (μmol/L) | 55.5 ± 8.0 | 61.7 ± 13.1 | 0.007 | 46.9 ± 36.3 | 52.5 ± 40.2 | 0.04 |
| Kynurenine (μmol/L) | 1.6 ± 0.4 | 1.8 ± 0.4 | 0.03 | 1.7 ± 0.5 | 1.9 ± 0.4 | n.s. |
| Kyn/Trp (μmol/mmol) | 28.6 ± 6.4 | 29.6 ± 7.6 | n.s. | 30.3 ± 8.5 | 30.2 ± 6.6 | n.s. |
| Tyrosine (μmol/L) | 62.8 ± 17.7 | 68.3 ± 17.3 | n.s. | 60.0 ± 12.6 | 61.8 ± 14.0 | n.s. |
| Phenylalanine (μmol/L) | 77.8 ± 11.8 | 77.6 ± 13.3 | n.s. | 76.7 ± 13.9 | 77.9 ± 10.8 | n.s. |
| Phe/Tyr (μmol/μmol) | 1.3 ± 0.2 | 1.2 ± 0.2 | 0.04 | 1.3 ± 0.2 | 1.2 ± 0.2 | n.s. |
(1) Significant differences between females and males after 3 months of treatment. (2) Significant differences between females and males after 6 months of treatment.