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. 2023 May 18;15(5):1527. doi: 10.3390/pharmaceutics15051527

Figure 2.

Figure 2

RvD1 and RvD2 attenuate the expression of neutrophil adhesion molecules and increase neutrophil apoptosis in vivo. (A) The animal protocol for analyzing neutrophil functions after the treatment with RvD1 and RvD2. (B) The expression of RvD1 and RvD2 receptors in mouse neutrophils via flow cytometry, and their quantitative analysis (C). (D) Adhesion molecules on neutrophils regulated by RvD1 and RvD2, and their quantification (E). (F) RvD1 and RvD2 promote the apoptosis of inflammatory neutrophils in mouse blood 5 h after LPS challenge of a 15 mg/kg i.p. injection, and their quantitative analysis (G). The data are expressed as the mean ± SDs, n = 3. A one-way ANOVA was applied to determine the difference among multiple groups, with * p ≤ 0.05, ** p ≤ 0.01, and *** p ≤ 0.001.