Figure 5.

The molecular mechanism of RvD1/RvD2 in regulating the inflammation resolution in the lung. LPS induces an inflammatory response in the lungs, and endothelial cells as well as neutrophils upregulate their adhesion molecules to promote neutrophil adhesion and transmigration in the lungs. If the inflammation is out of control, it may cause tissue damage and chronic inflammation; however, when treating it with resolvins, the adhesion molecule expression on endothelial cells (A) and neutrophils (B) is alleviated, thus mitigating neutrophil transmigration and neutrophil apoptosis. Next, resolvins enhance the macrophage phagocytosis of apoptotic neutrophils (C), thus maintaining tissue homeostasis in the lungs.