Table 8.
Stability data of rucaparib, niraparib, and olaparib in DBS samples.
| Analyte | Nominal Concentration (ng/mL) | 14 Days in Autosampler Conditions (Final Extract at 15 °C, Dark) (n = 3) | 219 Days in Desiccator Conditions (20 °C, Humidity < 35%) (n = 3) | ||||
|---|---|---|---|---|---|---|---|
| Mean Concentration (ng/mL) | CV% | Acc% | Mean Concentration (ng/mL) | CV% | Acc% | ||
| rucaparib | 255 | 257 | 2 | 101 | 252 | 1 | 99 |
| 4250 | 4336 | 5 | 102 | 4018 | 4 | 95 | |
| niraparib | 153 | 147 | 5 | 96 | 141 | 1 | 92 |
| 2550 | 2330 | 1 | 91 | 2301 | 3 | 90 | |
| olaparib | 357 | 356 | 6 | 100 | 368 | 1 | 103 |
| 5950 | 5964 | 3 | 100 | 6104 | 1 | 103 | |
Acc%, percentage of accuracy; CV%, coefficient of variation; n, number of replicates.