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. 2023 May 17;16(5):758. doi: 10.3390/ph16050758

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Compound 10b attenuated BDL-induced liver injury in rats. (A) Liver histopathology was observed by H&E and Sirius red staining (magnification 400×; top panel). The red arrows indicated the area of bile duct hyperplasia, accompanied by infiltration of monocytes, structural dysfunction, and proliferation of fibroblasts in the ductal region (H&E). The red arrows highlighted the location of collagen fiber accumulation in the portal area (Sirius red). (B,C) Blinded quantitative assessment of liver bile duct proliferation, necrosis, and inflammation. Additionally, the percentage of Sirius red positively strained areas. (D) mRNA expressions of fibrogenic genes in rat liver samples. Gapdh served as the loading control. The values are expressed as the mean ± SD. ##: p < 0.01, significantly different from sham group; *: p < 0.05, significantly different from BDL-NS group in; ANOVA, followed by Tukey’s test.