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NK cell-mediated ADCC activity of the ZV54 mAb glycovariants. The ZIKV-infected Vero cells (A) or uninfected Vero cells (B) were incubated with NK cells (E:T ratio = 5:1) in the presence of the ZV54 glycovariants or an IgG isotype negative control (hIgG). The percent of Vero cell lysis (mAb–NK cell-mediated ADCC target-cell killing) and the percent increase in ZV54 ADCC compared to the negative control hIgG were calculated. * and ns indicate p values of <0.05 and >0.05, respectively.
