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In vivo activity of the plant-made ZV54 glycovariants in mice. Five-weeks-old Ifnar1−/− mice were inoculated with ZIKV and administered ZV54WT or PBS (negative control) intraperitoneally 24 h after ZIKV infection. Blood was collected on day 3 post-infection, and viremia was quantitated by RT-qPCR (A). Mice were further monitored daily for survival to 20 days post-infection (B). The results are representative of two independent experiments. ** indicates a p value of 0.0065.
