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. 2023 May 19;15(5):1535. doi: 10.3390/pharmaceutics15051535
ADMET Absorption, distribution, metabolism, excretion and toxicity
BTs Bloodstream trypomastigotes
Bz Benznidazole
CCs Cultures of cardiac cells
EC50 Compound concentration that reduces 50% of the number of parasites
EC90 Compound concentration that reduces 90% of the number of parasites
CD Chagas disease
CDCl3 Deuterated chloroform
CEUA Committee of Ethics for the Use of Animals
COSY Homonuclear correlation spectroscopy
DEPT Distortionless enhancement by polarization transfer
DMSO Dimethyl sulfoxide
DTUs Discrete typing units
FBS Fetal bovine serum
FDA Food and Drug Administration
FICI Fractional inhibitory concentrations index
hERG Human ether-à-go-go-related gene
HMBC Heteronuclear multiple bond correlation
HSQC Heteronuclear single quantum coherence
LC50 The concentration that kills 50% of the parasite
Nf Nifurtimox
NMR Nuclear magnetic resonance
OsO4 Osmium tetroxide
Pb Plumbagin
P-gp P-glycoprotein
pKCSM Small-molecule pharmacokinetic and toxicity properties
SEM Scanning electron microscopy
SIs Selectivity indexes
T. cruzi Trypanosoma cruzi
TEM Transmission electron microscopy
TMS Tetramethylsilane
ΣFICIs Sum of fractional inhibitory concentration indexes
µg/mL Micrograms per milliliter
μM Micromolar