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. 2023 Apr 1;16(6):1203–1231. doi: 10.1111/1751-7915.14257

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© 2023 The Authors. Microbial Biotechnology published by Applied Microbiology International and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Bacillus subtilis proteostasis network Nascent polypeptide chains (NPCs) emerging from the ribosome are screened to determine their final locations using poorly understood signals within their N‐terminal regions. SRP and SecA targets proteins, respectively, to membrane or extracytoplasmic locations. Trigger factor interacts with cytoplasmic proteins as an intermediate in free folding and chaperone mediated (DnaKJ, GroEL/ES) folding pathways. Misfolded proteins, and proteins with post‐translational modifications or degrons are targeted for degradation by Hsp100 family proteases such as Clp or Lon. High concentrations of misfolded proteins form aggregate due to illicit inter‐ and intra‐molecular interactions.