Table 1.
Overview of the production methods of gelatin-based particles for the delivery of bioactive compounds.
| DDS Synthesis Technique |
DDS Type | Type of Gelatin |
Gelatin Source | Encapsulated Bioactive Compound |
Crosslinker | Ref. |
|---|---|---|---|---|---|---|
| Desolvation | Nanoparticles | Type A | Porcine skin | Ibuprofen sodium | CaCl2 | [105] |
| Didanosine | GA | [81] | ||||
| Moxifloxacin | GA | [106] | ||||
| Timol maleate | GA | [107] | ||||
| - | GA | [108] | ||||
| Type B | Bovine skin | Rutin | GA | [109] | ||
| Rosiglitazone | GA | [84] | ||||
| Type A and B | Porcine skin and bovine skin | BMP-2, bFGF | GA | [100] | ||
| Texas Red | GA | [76] | ||||
| Cardamom | GA | [77] | ||||
| Amphotericin B | GA | [78] | ||||
| Porcine skin and beef nails | Fluorescein-5-isothiocynate | GA | [79] | |||
| N. d. | Bovine skin | Bovine serum albumin | GA | [110] | ||
| Fish skin | - | GA | [111] | |||
| Camel skin | - | GA | [86] | |||
| Nanoprecipitation | Nanoparticles | Type B | Bovine skin | Lysozyme | DIC | [95] |
| - | – | [112] | ||||
| - | GA | [113] | ||||
| Fluorescein-5-isothiocynate | GA | [114] | ||||
| Dextran | GA | [70] | ||||
| Tizadine hydrochloride gatifloxacin | GA | [113] | ||||
| Metoprolol | GA | [90] | ||||
| N. d. | Porcine | Erythromycin | GA | [115] | ||
| N. d. | Cocoa-derived polyphenolic extract | GA | [102] | |||
| Type A | Porcine skin | Zaltoprofen | GA | [82] | ||
| Type A and B | Porcine skin and bovine skin | Non-steroidal anti-inflammatory drugs | GA | [80] | ||
| Coacervation | Microcapsules/nanocapsules | Type A | Porcine skin | α-Tocopherol | GA | [83] |
| Vitamin D3 | TG | [99] | ||||
| Capsaicin | GA | [116] | ||||
| N. d. | N. d. | Capsaicin | GA | [103] | ||
| N. d. | N. d. | Zeaxanthin | TG | [117] | ||
| N. d. | N. d. | Phenacetin | Formalin | [94] | ||
| N. d. | N. d. | Berberine hydrochloride Gallic acid |
– | [118] | ||
| Type B | Bovine skin | Geraniol oil | GA | [85] | ||
| N. d. | N. d. | Moxa oil | FA | [119] | ||
| N. d. | Fish | Fish oil | CaCl2 | [120] | ||
| Emulsion | Microspheres/nanospheres | Type B | N. d. | Mitomycin C-dextran conjugate | FA | [121] |
| Bovine skin | Sodium fluoride | GA | [88] | |||
| Type A | Porcine skin | TGF-β1 | Genepin | [27] | ||
| L929 fibroblasts | MBA | [93] | ||||
| Type A and B | N. d. | bFGF | GA | [122] | ||
| Porcine skin and bovine skin | BMP-2, VEGF | Genepin | [91] | |||
| N. d. | N. d. | Cefquinome sulfate | GA | [123] | ||
| N. d. | N. d. | Tetracycline hydrochloride | GA | [124] | ||
| N. d. | N. d. | Amoxicillin | GA | [125] | ||
| N. d. | N. d. | Phyllanthus urinaria extract | – | [101] | ||
| Microparticles/nanoparticles | Type B | Bovine skin | Bovine serum albumin | – | [126] | |
| BMP-4, bFGF | Heat | [98] | ||||
| Methotrexate | GA | [127] | ||||
| Type A | Porcine skin | Tramadol hydrochloride | GA | [128] | ||
| Type A and B | N. d. | BMP-2 | GA | [33] | ||
| Spray-dry | Microcapsules | Type A | N. d. | Revaprazan | – | [129] |
| N. d. | Curcumin | DCMC | [92] | |||
| N. d. | Nifedipine | – | [130] | |||
| N. d. | Valsaran | – | [131] | |||
| N. d. | Fenofibrate | – | [132] | |||
| N. d. | Ibuprofen | – | [133] | |||
| N. d. | Ibuprofen | GA | [134] | |||
| N. d. | Piroxicam | – | [135] | |||
| Electrospray | Nanocapsules | N. d. | Tilapia fish skin | Moringa oleifera | – | [136] |
| Microparticles/nanoparticles | N. d. | N. d. | Piroxicam | – | [87] | |
| N. d. | Tilapia fish skin | Bitter gourd | – | [137] | ||
| Type A | Porcine skin | Epigallocatechin 3-gallate | GA | [89] | ||
| Microspheres | Type B | Bovine skin | Human bone marrow stromal cell | CaCl2 | [96] | |
| N. d. | Human-adipose-derived stem cells | – | [104] |