Table 1.
In vitro and in vivo assays performed to investigate seaweed polyphenols neuroprotective activity.
| Species | Extracted Compound | Exhibited Effect | In Vitro/ In Vivo Assay |
References |
|---|---|---|---|---|
| Ecklonia cava | Dieckol Phlorofucofuroeckol |
Inhibition of AChE. Potential ability to enhance memory in neurodegenerative disorders |
In vivo (Ethanol pre-treated mice) |
[105] |
| Ecklonia cava | Phloroglucinol | Limited increase in ROS accumulation | In vitro (SH-SY5Y cells) |
[104] |
| reduction in dendritic spine density in mice | In vivo (5XFAD mice) |
|||
| Ecklonia cava | Phloroglucinol | Improvement of cognitive impairments | In vivo (5XFAD mice) |
[106] |
| Ecklonia kurome | Dieckol phlorofucofuroeckol-A 974-A 974-B |
All compounds showed ROS scavenging activity | In vitro (DCFH-DA assay) |
[93] |
| Ecklonia maxima | Eckmaxol | Neuroprotective activity prevention aggregation of β-amyloid |
In vitro (SH-SY5Y cells) |
[102] |
| Ecklonia radiata | Eckol-type phlorotannins | Neuroprotective activity | In vitro (PC12 cells) |
[98] |
| Ecklonia radiata | Phlorotannin | Apoptosis inhibition. Neuroprotective activity |
In vitro (PC12 cells) |
[97] |
| Ecklonia sp. | Eckol Dieckol Phlorofucofuroeckol-A 974-A |
All compounds showed ROS scavenging activity. Phlorofucofuroeckol-A and 974-A showed neuroprotective activity |
In vitro (PC12 cells) |
[92] |
|
Fucus guiryi
Fucus serratus Fucus spiralis Fucus vesiculosus |
Phlorotannin | All compounds showed ROS scavenging activity (stronger activity for Fucus guiryi and Fucus serratus extracts) | In vitro (SH-SY5Y cells) |
[94] |
|
Fucus vesiculosus
Undaria pinnatifida |
Phlorotannin-rich fucoidan Fucoidan |
Neuroprotective activity. prevention aggregation of β-amyloid |
In vitro (PC12 cells) |
[100] |
| Fucus vesiculosus Pelvetia canaliculata | Phlorotannin | Neuroprotective activity | In vitro (SH-SY5Y cells) |
[105] |