Table 5.

Summary of various delivery systems and polymers used for the solubilization of different drug molecules.

Delivery System/Method Employed	Polymer Used	Drugs/API	Structure	Details	References
PAMAM Dendrimer	Amine and ester-terminated PAMAM Dendrimers	Nifedipine		Dendrimers composed of poly (amidoamine), or PAMAM, can improve the solubility of insoluble drugs in water at pH 7.	[163]
	Dendrimers made of polyamidoamine(PAMAM) G3.5 and PAMAM G4.5.	Oxaliplatin		The solubility of oxaliplatin increases roughly linearly with dendrimer concentration.	[164]
	Dendrimers made from PAMAM	Temozolomid		TMZ solubility was shown to be enhanced in some solvent systems, with dendrimer, ethanol, and tween-20 showed construction and related in solubility.	[165]
	PAMAM dendrimers with pyrrolidone modification	Indomethacin		The drug’s solubility and intracellular delivery are being improved	[166]
	PAMAM dendrimers	Nicotinic acid		PAMAM dendrimers of different generations (G1–G4) have the ability to dramatically improve nicotinic acid solubility.	[167]
	Polyether dendrimer	Artemether		Due to their excellent water solubility, non-immunogenicity, and increased biocompatibility, they are used as drug carriers.	[168]
	PAMAM dendrimers	Ibuprofen		PAMAM dendrimers improve ibuprofen solubility much more than SDS micelles.	[169]
	PAMAM and Lauryl PAMAM dendrimer	Propranolol		Propranolol’s solubility has been improved	[170]
Silica	Cur-fls & Cur-sls	Curcumin		Improved solubility with enhanced oral bioavailability up to 7-fold high than convectional suspensions.	[171]
Thin film hydration sonication	Glycol, Eudragit S100	Sorafenib		It improved systemic exposure of about four-fold.	[172]
Thin-film hydration sonication	Lecithin	Cefotaxime		About five-fold increase of in oral bioavailability and improved solubility	[173]
Thin-film hydration sonication	Soy lecithin	Capsaicin		Oral bioavailability and improved solubility increase about three-fold.	[174]
Film deposition on the carrier	HSPC	Lopinavir		Improved solubility with enhanced oral bioavailability up to 2-fold.	[175]
Thin-film hydration sonicate	DSPC	Asinine maleate		About one-fold increase in oral bioavailability and improved solubility	[176]
Thin-film hydration sonication-freeze thawing	SPC	Spironolactone		Enhanced oral bioavailability with improved solubility up to 2-fold.	[177]
High-pressure homogenization	Poly Na styrene sulfonate	Paclitaxel		About 14 -fold increase in oral bioavailability and improved solubility and drug dissolution: 20% (120 min).	[178]
Antisolvent precipitation	Pluronic® F68	Puerarin		Enhanced oral bioavailability with improved solubility up to 4-fold	[179]
Spray drying	SDS	Alisertib isoproxil		Drug dissolution: ~14% (1/2 min) enhanced oral bioavailability with improved solubility up to 4-fold.	[180]
Antisolvent precipitation	Ethyl cellulose	Domperidone		Fifty percent (30 min) and 65 percent (60 min) drug dissolution and enhanced oral bioavailability with improved solubility up to 2-fold.	[181]
Precipitation-sonication	PVA	Cinnarizine		One hundred percent drug in dissolution (240 s) enhanced oral bioavailability with improved solubility up to 2-fold.	[182]
Magnetic stirring-milling	PVP-K30	Glyburide		100 percent drug in dissolution (30 min) increased oral bioavailability with improved solubility up to four-fold.	[183]
Hot homogenization sonication	Stearic acid	Rosuvastatin		Drug release: ~45 percent (120 min) and ~80 percent (10 h) Improved oral bioavailability with improved solubility up to 8-fold.	[184]
Micro emulsification	Compritol	Rifampicin		Enhanced oral bioavailability with increased solubility up to 8-fold.	[185]
Emulsification sonication	Precirol® ATO-5, palmitic acid, Gelucire® 50/13, N	Resveratrol		Enhanced oral bioavailability and having a higher level of solubility up to 7-fold.	[186]