Figure 6.

Representation of yellow fever (YF) pathway development. This figure illustrates the sequence of events in YF-related disease development, starting with the bite of an infected mosquito and ending with apoptosis and a heightened inflammatory reaction. The presence of the yellow fever virus (YFV) is indicated by a distinct color. It is hypothesized that intense viral replication in the liver sets off a series of molecular reactions, leading to considerable disruption in cytokine balance and an increased release of pro-inflammatory substances. Consequently, this results in substantial vascular impairment and multi-organ malfunction.