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Proposed mechanisms of VITT pathogenesis. Anti-PF4 antibodies induce platelet aggregation, neutrophil and monocyte activation that activate coagulation and inflammation, and ultimately progresses to thrombosis. Extracellular neutrophil traps (NETs); platelet factor 4 (PF4). NETosis, or NET activation and release, is a dynamic process that can come in two forms, suicidal and vital NETosis. Overall, many of the key components of the process are similar for both types of NETosis.
