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Augmented cancer–immunity cycle. The classic activation, through MHCI-CD8-acivated T cells, is on the upper side. The MHCII-CD4-NK axis is at the bottom. Ag—antigen, Ab—antibody, TCR—T cell receptor, and FcγIIIa—low affinity immunoglobulin gamma Fc region receptor III-A (CD16a).
