Figure 2.

Oncometabolites from glucose metabolism. Oncometabolites derived from dysregulated glucose metabolism in peritoneal cancers, including glycolysis, the tricarboxylic acid cycle (TCA cycle), and the pentose phosphate pathway (PPP), are presented. Oncometabolites arising from deregulated TCA cycle include pyruvate, α-ketoglutarate (α-KG), succinate, fumarate, and 2-hydroxyglutarate (2-HG). Oncometabolites from dysregulated glycolytic shift include increased levels of glucose, glyceraldehyde-3-phosphate (G3P), pyruvate, and lactate. Oncometabolites derived from the PPP are nicotinamide adenine dinucleotide phosphate (NADPH), G3P, and 6-phosphogluconate (6PG). Other abbreviations are GLUT, Glucose Transporters; F6P, Fructose-6-phosphate; DHAP, Dihydroxyacetone phosphate; OAA, Oxaloacetate; and RuBP, Ribulose-1,5-bisphosphate.