Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 30;13(5):618. doi: 10.3390/metabo13050618

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Oncometabolites from nucleotide metabolism. Oncogenic intermediates are generated by the deregulated metabolism of purines, pyrimidines, and their cofactors in peritoneal cancers. Oncometabolites resulting from purine metabolism include inosine monophosphate (IMP) and 5-phosphoribosyl-1-pyrophosphate (PRPP) while oncometabolites generated by pyrimidine metabolism include dihydroorotate (DHO), orotate, PRPP, and thymidine. The major cofactors involved in purine and pyrimidine metabolisms that act as oncometabolites are nicotinamide mononucleotide (NMN), nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP), dihydrofolate (DHF), and tetrahydrofolate (THF). The abbreviations denote A, Adenine; G, Guanine; U, Uracil; T, Thymine; C5P, Carbamoyl-5-phosphate; UTP, Uridine triphosphate; CTP, Cytidine triphosphate; dCTP, Deoxycytidine triphosphate; dUTP-Deoxyuridine triphosphate; dTMP-Deoxythymidine monophosphate; dTTP, Deoxythymidine triphosphate; Ru5P, Ribulose-5-phosphate; Gln, Glutamine; ATP, Adenosine triphosphate; GTP, Guanosine triphosphate; dATP, Deoxyadenosine triphosphate; and dGTP, Deoxyguanosine triphosphate.