Figure 1.

Effect of Lacticaseibacillus rhamnosus CRL1505 on lung colonization and damage induced by KPC-2-producing hypermucoviscous Klebsiella pneumoniae ST25 strains. BALB/c mice (6 weeks old) were orally treated with the CRL1505 strain for 5 days and then challenged nasally with K. pneumoniae LABACER 01 (Kp01) or LABACER 27 (Kp27). Before (basal) and two days after challenge, bacteria cell counts in lung homogenates, broncho–alveolar lavages (BAL) lactate dehydrogenase (LDH) activity and albumin concentration were determined. Results represent data from three independent experiments. Asterisks indicate significant differences between the indicated groups, (*) p < 0.05, (**) p < 0.01. Basal levels of BAL albumin were below the detection limit. ND: not detected. Pink bars represent mice given Lcb. rhamnosus CRL1505 and blue bars represent control mice.