Figure 4.

Effect of Lacticaseibacillus rhamnosus CRL1505 on respiratory and blood inflammatory chemokines induced by KPC-2-producing hypermucoviscous Klebsiella pneumoniae ST25 strains. BALB/c mice (6 weeks old) were orally treated with the CRL1505 strain for 5 days and then challenged nasally with K. pneumoniae LABACER 01 (Kp01) or LABACER 27 (Kp27). Before (basal) and two days after challenge, KC and MCP-1 levels were determined in broncho–alveolar lavages (BAL) and serum. Results represent data from three independent experiments. Asterisks indicate significant differences between the indicated groups, (**) p < 0.01. Pink bars represent mice given Lcb. rhamnosus CRL1505 and blue bars represent control mice.