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. 2023 Apr 29;15(5):1365. doi: 10.3390/pharmaceutics15051365

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Killing rate (k) values of micafungin (left) and micafungin plus nikkomycin Z (right) in RPMI 1640 against South Asian (isolates 20, 27, 28, 196 and 208), East Asian (type strain = NCPF 13029 = CBS 10913, and isolates 12372 and 12373), South African (isolates 2, 204 and 206) and South American (isolates I-24 and I-156 from Israel and hospital environmental isolates 13108 and 16565 from Colombia) clades. Micafungin was tested at 0.25, 1, 8, 16 and 32 mg/L with (8 mg/L) and without nikkomycin Z. Positive and negative k values indicate a decrease and increase, respectively, in viable cell numbers. Error bars were omitted for better visualization of the graphics.