Table 1.
MIC values of anidulafungin (ANI), micafungin (MICA) and nikkomycin Z (NIK) in RPMI 1640 against Candida auris isolates and type strain. MICs were determined using the CLSI broth microdilution method.
| Isolates Number | Clade | Body Site | FKS Mutation | MIC (mg/L) | ||
|---|---|---|---|---|---|---|
| ANI | MICA | NIK | ||||
| 20 | South Asian | Wound swab | HS1 WT HS2 R1354H |
0.25 | 0.25 | 2 |
| 27 (NCPF 8991) | South Asian | Pleural fluid | HS1 WT HS2 WT |
0.12 | 0.25 | >16 |
| 28 (NCPF 8992) | South Asian | Central line | HS1 S639Y HS2 WT |
4 | 4 | 16 |
| 196 | South Asian | Blood | HS1 WT HS2 WT |
0.12 | 0.25 | >16 |
| 208 | South Asian | Screening swab | HS1 S639P HS2 WT |
0.5 | 2 | 16 |
| Type strain (NCPF 13029 = CBS 10913) |
East Asian | External ear | HS1 WT HS2 WT |
0.03 | 0.12 | >16 |
| 12372 (CBS 12372) | East Asian | Blood | HS1 WT HS2 WT |
0.03 | 0.03 | >16 |
| 12373 (CBS 12373) | East Asian | Blood | HS1 WT HS2 WT |
0.06 | 0.06 | 16 |
| 2 (NCPF 8977) | South African | CSF | HS1 WT HS2 WT |
0.03 | 0.25 | 8 |
| 204 | South African | Tracheostomy | HS1 WT HS2 WT |
0.03 | 0.12 | >16 |
| 206 | South African | Blood | HS1 WT HS2 WT |
0.06 | 0.25 | 4 |
| I-24 | South American (Israel) |
Blood | HS1 WT HS2 WT |
0.06 | 0.12 | 4 |
| I-156 | South American (Israel) |
Blood | HS1 WT HS2 WT |
0.06 | 0.12 | 4 |
| 13108 (CDC B-13108) | South American (Colombia) |
Hospital environment |
HS1 WT HS2 WT |
0.06 | 0.12 | 4 |
| 16565 (CDC B-16565) | South American (Colombia) |
Hospital environment |
HS1 WT HS2 WT |
0.015 | 0.06 | 8 |