Table 3.

Maximum changes in log CFU/mL compared to the starting inoculum in time–kill studies at different micafungin (mg/L), and micafungin (mg/L) plus 8 mg/L nikkomycin Z concentrations (mg/L) for the four Candida auris clades. Data in bold and underlined indicate a synergistic (more than 2 log CFU decreases in CFU) and fungicidal effect (at least 3 log decreases in CFU), respectively.

Clade	Isolate Number	Maximum Log Decreases/Increases in CFU in Time–Killing Experiments at the Indicated Micafungin and Micafungin + Nikkomycin Z Concentrations
		Micafungin (mg/L)				Micafungin (mg/L) +Nikkomycin Z (mg/L)
		0.25	1	8	16	32	0.25 + 8	1 + 8	8 + 8	16 + 8	32 + 8
South Asian	20	+1.02	−0.47 *	−0.35 *	−0.52 *	−0.44 *	−1.78	−1.68	−1.13	−0.95	−1.38 *
	27	−1.68	−2.51	−1.43	−1.27	−1.30	−2.38	−2.40	−2.51	−2.84	−3.6
	28	+1.45	+1.34	−0.83 *	−0.35 *	−0.44 *	+1.52	−0.16 *	−0.70 *	−0.57 *	−0.52 *
	196	−0.51	−0.69	−0.32	−0.24	−0.24	−2.32	−2.15	−2.62	−2.62	−2.72
	208	+1.67	+1.89	−0.08 *	−0.14 *	+1.13	+1.72	+1.52	−0–04 *	−0.04 *	−0.13 *
East Asian	Type strain	−0.67 *	−0.60	−0.56	−0.49 *	−0.51 *	−0.69	−0.64	−0.64	−0.54	−0.62
	12372	−0.54 *	−0.67 *	−0.54 *	−0.64 *	−0.72 *	−1.51	−1.90	−2.12	−2.54	−3.15
	12373	−0.30 *	−0.39 *	−0.52 *	−0.33 *	−0.39 *	−1.47	−1.49	−1.70	−1.74	−2.64
South African	2	+0.37	+0.34	+0.26	+0.36	+0.21	−1.46	−1.50	−1.60	−1.67	−2.48
	204	−0.08 *	−0.11 *	−0.05 *	−0.05 *	−0.11 *	−0.56	−0.65	−0.65	−0.78	−0.88
	206	+0.54	+0.51	+0.60	+0.48	+0.48	−0.23 *	−0.23 *	−0.23 *	−0.16 *	−0.22 *
South American (from Israel)	I−24	−0.30 *	−0.24 *	−0.19 *	−0.15 *	−0.24 *	−0.65	−0.83	−0.69 *	−0.83	−0.79
	I−156	−0.18 *	−0.30 *	−0.35 *	−0.35 *	−0.30 *	−1.30	−1.52	−1.49	−1.48	−1.42
South American (from Colombia)	13108	−0.86 *	−0.86 *	−0.95 *	−1.08 *	−1.08	−3.13	−3.35	−4.26	−4.26	−4.26
	16565	−1.15	−1.15	−0.79 *	−0.59 *	−0.77 *	−4.26	−4.26	−4.26	−4.26	−4.26

* Regrowth.