Table 3.
History of comorbidities, overall and by drug of first injection.
| Overall | Aflibercept | Bevacizumab | Dexamethasone | Ranibizumab | Pegaptanib | |
|---|---|---|---|---|---|---|
| TOTAL, N (%) | 16,226 | 4230 (26.1) | 593 (3.6) | 2500 (15.4) | 8731 (53.8) | 172 (1.1) |
| Charlson Comorbidity Index | ||||||
| Mean (standard deviation) | 0.5 (1.2) | 0.4 (1.1) | 0.4 (1.1) | 0.6 (1.4) | 0.4 (1.2) | 0.4 (1.0) |
| Number of comorbidities (one of those present in Table) | ||||||
| Mean (standard deviation) | 0.9 (1.1) | 0.8 (1.0) | 0.8 (1.0) | 1.0 (1.1) | 0.9 (1.0) | 0.9 (1.1) |
| Median (interquartile range) | 1.0 (0.0–1.0) | 1.0 (0.0–1.0) | 1.0 (0.0–1.0) | 1.0 (0.0–2.0) | 1.0 (0.0–1.0) | 0.0 (0.0–2.0) |
| Group, N (%) | ||||||
| 0 | 7471 (46.0) | 2049 (48.4) | 284 (47.9) | 974 (39.0) | 4076 (46.7) | 88 (51.2) |
| 1–2 | 7468 (46.0) | 1866 (44.1) | 270 (45.5) | 1271 (50.8) | 3992 (45.7) | 69 (40.1) |
| 3–5 | 1253 (7.7) | 307 (7.3) | 39 (6.6) | 249 (10.0) | 643 (7.4) | 15 (8.7) |
| 6+ | 34 (0.2) | 8 (0.2) | - | 6 (0.2) | 20 (0.2) | - |
| Psychiatric or mental health conditions, N (%) | ||||||
| Anxiety | 132 (0.8) | 25(0.6) | 4 (0.7) | 20 (0.8) | 83 (1.0) | - |
| Bipolar disease | 27 (0.2) | 8 (0.2) | 1 (0.2) | 3 (0.1) | 15 (0.2) | - |
| Delirium | 15 (0.1) | 1 (0.0) | - | 4 (0.2) | 10 (0.1) | - |
| Dementia | 28 (0.2) | 7 (0.2) | 1 (0.2) | 6 (0.2) | 13 (0.1) | 1 (0.6) |
| Depression | 46 (0.3) | 7 (0.2) | - | 9 (0.4) | 30 (0.3) | - |
| Non-schizophrenic psychosis | 29 (0.2) | 7 (0.2) | - | 2 (0.1) | 20 (0.2) | - |
| Schizophrenia | 17 (0.1) | 2 (0.0) | - | 3 (0.1) | 12 (0.1) | - |
| Cardio/cerebrovascular diseases, N (%) | ||||||
| Arrhythmia | 251 (1.5) | 81 (1.9) | 2 (0.3) | 44 (1.8) | 123 (1.4) | 1 (0.6) |
| Congestive heart failure | 323 (2.0) | 80 (1.9) | 13 (2.2) | 49 (2.0) | 178 (2.0) | 3 (1.7) |
| Ischemic heart disease | 1166 (7.2) | 302 (7.1) | 29 (4.9) | 204 (8.2) | 608 (7.0) | 23 (13.4) |
| Stroke | 224 (1.4) | 60 (1.4) | 7 (1.2) | 46 (1.8) | 108 (1.2) | 3 (1.7) |
| Hypertension | 4961 (30.6) | 1262 (29.8) | 185 (31.2) | 875 (35.0) | 2583 (29.6) | 56 (32.6) |
| Peripheral arterial disease | 28 (0.2) | 11 (0.3) | - | 7 (0.3) | 10 (0.1) | - |
| Valve disorders | 224 (1.4) | 54 (1.3) | 5 (0.8) | 36 (1.4) | 127 (1.5) | 2 (1.2) |
| Venous thrombosis embolism | 75 (0.5) | 12 (0.3) | 1 (0.2) | 28 (1.1) | 33 (0.4) | 1 (0.6) |
| Other conditions, N (%) | ||||||
| Diabetes | 5561 (34.3) | 1287 (30.4) | 215 (36.3) | 1072 (42.9) | 2941 (33.7) | 46 (26.7) |
| COPD | 373 (2.3) | 102 (2.4) | 10 (1.7) | 52 (2.1) | 204 (2.3) | 5 (2.9) |
| Osteoporosis | 106 (0.7) | 34 (0.8) | 5 (0.8) | 10 (0.4) | 56 (0.6) | 1 (0.6) |
| Parkinson’s disease | 38 (0.2) | 7 (0.2) | - | 11 (0.4) | 19 (0.2) | 1 (0.6) |
| Epilepsy | 67 (0.4) | 23 (0.5) | 2 (0.3) | 14 (0.6) | 26 (0.3) | 2 (1.2) |
| Hip fracture | 35 (0.2) | 10 (0.2) | 1 (0.2) | 4 (0.2) | 20 (0.2) | - |
| Pneumonia | 316 (1.9) | 81 (1.9) | 6 (1.0) | 51 (2.0) | 176 (2.0) | 2 (1.2) |