Table 2.
Cytotoxicity of fractions from G. robertianum hexane and ethyl acetate extracts.
| Fractions | VERO | FaDu | Detroit 562 | RKO | |||
|---|---|---|---|---|---|---|---|
| CC50 | CC50 | SI | CC50 | SI | CC50 | SI | |
| GrH1 | 330.05 ± 26.23 | 203.95 ± 23.41 | 1.62 | 273.65 ± 20.58 | 1.21 | 238.5 ± 22.97 | 1.38 |
| GrH2 | 302.5 ± 3.25 | 142.55 ± 22.27 | 2.12 | 224.85 ± 20.44 | 1.35 | 168.62 ± 11.39 | 1.79 |
| GrH3 | 288.2 ± 5.94 | 101.9 ± 1.13 | 2.83 | 102.69 ± 4.55 | 2.81 | 99.52 ± 6.68 | 2.90 |
| GrH4 | 180.15 ± 6.72 | 67.62 ± 2.84 | 2.66 | 129.85 ± 6.86 | 1.39 | 89.68 ± 4.52 | 2.01 |
| GrH5 | 113.3 ± 8.49 | 46.25 ± 3.92 | 2.45 | 88.71 ± 4.74 | 1.28 | 49.16 ± 1.46 | 2.30 |
| GrH6 | 70.88 ± 3.77 | 22.04 ± 1.82 | 3.22 | 48.71 ± 1.36 | 1.46 | 29.59 ± 0.99 | 2.40 |
| GrH7 | 30.82 ± 0.31 | 13.35 ± 1.11 | 2.31 | 31.87 ± 0.25 | 0.97 | 187.0 ± 14.9 | 0.16 |
| GrH8 | 34.15 ± 0.14 | 18.51 ± 2.52 | 1.85 | 34.61 ± 0.32 | 0.99 | 125.10 ± 9.43 | 0.27 |
| GrEA1 | 289.07 ± 16.05 | 82.69 ± 1.94 | 3.50 | 168.80 ± 7.5 | 1.71 | 89.67 ± 5.42 | 3.22 |
| GrEA2 | 147.87 ± 4.66 | 49.02 ± 4.54 | 3.02 | 93.78 ± 5.02 | 1.58 | 65.6 ± 1.07 | 2.25 |
| GrEA3 | 65.01 ± 0.62 | 19.86 ± 0.73 | 3.27 | 45.06 ± 6.05 | 1.44 | 26.73 ± 1.28 | 2.43 |
| GrEA4 | 43.83 ± 3.23 | 14.22 ± 1.43 | 3.08 | 27.98 ± 6.50 | 1.57 | 22.55 ± 0.61 | 1.94 |
| GrEA5 | 43.46 ± 0.29 | 17.89 ± 0.68 | 2.43 | 40.23 ± 3.44 | 1.08 | 39.28 ± 2.09 | 1.11 |
| GrEA6 | 67.29 ± 3.54 | 35.48 ± 4.89 | 1.90 | 61.55 ± 6.33 | 1.09 | 51.86 ± 1.15 | 1.30 |
CC50—50% cytotoxic concentration (µg/mL); mean ± SD; SI—selectivity index (SI = CC50VERO/CC50CancerCells); GrH1–GrH8—fractions 1–8 from hexane extract; GrEA1–GrEA6—fractions 1–6 from ethyl acetate extract; cell lines: VERO—green monkey kidney; FaDu—human hypopharyngeal squamous cell carcinoma; Detroit 562—human pharyngeal carcinoma; RKO—human colon cancer.