Table 1.

List of the main neurological and neurodegenerative diseases correlated with Nav channel dysfunctions.

Nav Isoform	Gene	Neurological Disorder	References	Neurodegenerative Disorder	References
Nav1.1	SCN1A
		Dravet Syndrome	[51,52]	Alzheimer’s Disease	[53]
		GEFS+ (genetic epilepsy with febrile seizures plus)	[52,54,55]	Parkinson’s Disease	[56]
		Epilepsy of infancy with migrating focal seizures	[52,54]
		Myoclonic-atonic epilepsy	[52,54]
		Familial hemiplegic migraine	[32]
Nav1.2	SCN2A
		Developmental and epileptic encephalopathy (DEE).	[52,57]	Alzheimer’s disease	[53]
		Benign Familial Neonatal-Infantile Seizures (BFNIS)	[52,57]
		West syndrome	[38,58]
		Epilepsy of infancy with migrating focal seizures (EIMFS)	[52,54]
		Autism Syndrome Disorder (ASD)	[58]
		Intellectual Disability	[58]
		Episodic ataxia	[59]
Nav1.3	SCN3A
		Developmental and Epileptic Encephalopathy (DEE)	[60]	Parkinson’s Disease	[61]
		Polymicrogyria	[60]
		Intellectual Disability	[60]
Nav1.4	SCN4A
				Amyotrophic Lateral Sclerosis	[62]
				Huntington’s Disease	[63]
Nav1.5	SCN5A
				Multiple Sclerosis	[64,65]
NaX	SCN7A
				Amyotrophic Lateral Sclerosis	[66]
Nav1.6	SCN8A
		Developmental and epileptic encephalopathy (DEE).	[52]	Alzheimer Disease	[67,68]
		Autism Syndrome Disorder (ASD)	[52]	Amyotrophic Lateral Sclerosis	[69]
		Intellectual Disability	[70,71]	Multiple Sclerosis	[72]
Nav1.8	SCN10A
				Multiple Sclerosis	[64,73]