Table 3.
The statistically significant metabolites for the discrimination of the two groups, late preterm neonates with RDS and control NICU late preterms, according to the univariate analysis.
| Day | Metabolites | p-Values | Group Levels |
|---|---|---|---|
| 1st | 1-Methylnicotinamide | 0.0013 | control NICU > RDS |
| Glycine | 4.29 × 10−7 | control NICU > RDS | |
| Formate | 9.66 × 10−9 | RDS > control NICU | |
| Alanine | 2.80 × 10−5 | control NICU > RDS | |
| Hippurate | 0.008 | control NICU > RDS | |
| Glucose | 1.74 × 10−5 | control NICU > RDS | |
| Lactose | 0.00017 | RDS > control NICU | |
| 4-Hydroxyproline | 0.0066 | RDS > control NICU | |
| Gluconate | 0.0004 | RDS > control NICU | |
| Dimethylglycine | 1.98 × 10−6 | RDS > control NICU | |
| Myoinositol | 0.0063 | RDS > control NICU | |
| Acetoacetate | 2.42 × 10−6 | RDS > control NICU | |
| Leucine | 3.54 × 10−7 | control ICU > RDS | |
| Allantoin | 0.00107 | RDS > control NICU | |
| Betaine | 2.42 × 10−6 | control ICU > RDS | |
| Creatine | 0.0006 | RDS > control NICU | |
| Tyrosine | 0.007 | control ICU > RDS | |
| 4-Hydroxybenzoate | 0.0004 | control ICU > RDS | |
| Pyruvate | 0.00017 | RDS > control NICU | |
| Dimethylamine | 3.54 × 10−7 | control ICU > RDS | |
| Trimethylamine | 0.006 | control ICU > RDS | |
| Dimethylglycine | 2.85 × 10−5 | RDS > control NICU | |
| Oxoglutarate | 0.00017 | control NICU > RDS | |
| Ethanolamine | 0.0006 | RDS > control ICU | |
| TMAO | 0.0024 | control NICU > RDS | |
| 1-Methylnicotinamide, N1-Methyl-2-pyridone-5-carboxamide | 3.60 × 10−5 | control NICU > RDS | |
| Hypoxanthine | 0.0008 | control NICU > RDS | |
| Trigonelline | 0.0015 | control NICU > RDS | |
| 4-Hydroxyphenyl acetate | 3.64 × 10−6 | control NICU > RDS | |
| 3-Hydroxyisovaleric acid | 0.005 | control NICU > RDS | |
| Indoxyl sulfate | 0.0037 | RDS > control NICU | |
| 3rd | 1-Methylnicotinamide | 4.96 × 10−5 | RDS > control NICU |
| Glycine | 1.04 × 10−7 | RDS > control NICU | |
| Formate | 0.0011 | RDS > control NICU | |
| Alanine | 3.84 × 10−7 | RDS > control NICU | |
| Hippurate | 2.55 × 10−5 | control NICU > RDS | |
| Lactose | 0.0058 | control NICU > RDS | |
| 4-Hydroxyproline | 4.30 × 10−6 | control NICU > RDS | |
| Gluconate | 6.28 × 10−5 | RDS > control ICU | |
| Dimethylglycine | 0.0015 | control NICU > RDS | |
| Myoinositol | 1.24 × 10−5 | control NICU > RDS | |
| Acetoacetate | 0.00044 | RDS > control NICU | |
| Leucine | 0.0092 | RDS > control NICU | |
| Betaine | 1.05 × 10−6 | RDS > control NICU | |
| Tyrosine | 4.32 × 10−5 | control NICU > RDS | |
| 4-Hydroxybenzoate | 0.00015 | control NICU > RDS | |
| Pyruvate | 0.0033 | control NICU > RDS | |
| Dimethylamine | 1.05 × 10−6 | control NICU > RDS | |
| Trimethylamine | 3.84 × 10−7 | RDS > control ICU | |
| Dimethylglycine | 5.04 × 10−5 | control NICU > RDS | |
| Oxoglutarate | 7.32 × 10−5 | control NICU > RDS | |
| Ethanolamine | 5.04 × 10−5 | control NICU > RDS | |
| Taurine | 0.0011 | RDS > control NICU | |
| 1-Methylnicotinamide, N1-Methyl-2-pyridone-5-carboxamide | 5.38 × 10−5 | RDS > control NICU | |
| Hypoxanthine | 1.20 × 10−5 | RDS > control NICU | |
| Trigonelline | 0.0062 | RDS > control NICU | |
| 4-Hydroxyphenyl acetate | 2.31 × 10−5 | control NICU > RDS | |
| Lys/Arg | 3.26 × 10−6 | control NICU > RDS | |
| 3-Hydroxyisovaleric acid | 6.82 × 10−5 | control NICU > RDS | |
| Indoxyl sulfate | 0.0021 | RDS > control NICU |