Table 4.
Pathway analysis results of the urine metabolite comparison between late preterms with RDS and control NICU late preterms.
| No. | Biochemical Pathway | Metabolites Measured | Row p Value | Impact |
|---|---|---|---|---|
| 1 | Arginine and proline metabolism | Creatine, Hydroxyproline, Pyruvate | 1.86 × 10−1 | 0.07 |
| 2 | Taurine and hypotaurine metabolism | Taurine | 3.08 × 10−1 | 0.43 |
| 3 | Pyruvate metabolism | Pyruvate | 3.40 × 10−1 | 0.21 |
| 4 | Inositol phosphate metabolism | myo-Inositol | 3.52 × 10−1 | 0.13 |
| 5 | Phosphatidylinositol signaling system | myo-Inositol | 3.52 × 10−1 | 0.04 |
| 6 | Primary bile acid biosynthesis | Glycine, Taurine | 3.32 × 10−1 | 0.02 |
| 7 | Cysteine and methionine metabolism | Pyruvate; | 3.40 × 10−1 | 0.00 |
| 8 | Ascorbate and aldarate metabolism | myo-Inositol | 3.52 × 10−1 | 0.00 |
| 9 | Ubiquinone and other terpenoid-quinone biosynthesis |
Tyrosine | 4.26 × 10−1 | 0.00 |
| 10 | Phenylalanine, tyrosine, and tryptophan biosynthesis |
Tyrosine | 4.26 × 10−1 | 0.50 |
| 11 | Glycine, serine, and threonine metabolism | Betaine, N, N-Dimethylglycine, Glycine, Creatine, Pyruvate | 5.71 × 10−1 | 0.37 |
| 12 | Tyrosine metabolism | Tyrosine, Pyruvate, Acetoacetate, 4-Hydroxyphenylacetate | 4.83 × 10−1 | 0.14 |
| 13 | Glycolysis/Gluconeogenesis | Pyruvate, beta-Glucose | 5.14 × 10−1 | 0.10 |
| 14 | Butanoate metabolism | Acetoacetate, 2-Oxoglutarate | 5.95 × 10−1 | 0.11 |
| 15 | Citrate cycle (TCA cycle) | 2-Oxoglutarate, pyruvate | 5.92 × 10−1 | 0.10 |
| 16 | Alanine, aspartate, and glutamate metabolism |
2-Oxoglutarate, pyruvate | 5.92 × 10−1 | 0.05 |
| 17 | D-Glutamine and D-glutamate metabolism |
2-Oxoglutarate | 5.94 × 10−1 | 0.00 |
| 18 | Phenylalanine metabolism | Hippurate; Tyrosine | 6.22 × 10−1 | 0.00 |
| 19 | Valine, leucine, and isoleucine biosynthesis | Tyrosine | 7.16 × 10−1 | 0.00 |
| 20 | Purine metabolism | Hypoxanthine | 8.22 × 10−1 | 0.02 |
| 21 | Glyoxylate and dicarboxylate metabolism |
Glycine, Pyruvate, Formate | 8.71 × 10−1 | 0.11 |
| 22 | Glutathione metabolism | Glycine | 8.69 × 10−1 | 0.09 |
| 23 | Pentose phosphate pathway | Gluconate | 9.15 × 10−1 | 0.05 |
| 24 | Porphyrin metabolism | Glycine | 8.69 × 10−1 | 0.00 |
| 25 | Valine, leucine, and isoleucine degradation | Acetoacetate, Leucine | 8.88 × 10−1 | 0.00 |
| 26 | Nicotinate and nicotinamide metabolism | 1-Methylnicotinamide | 9.77 × 10−1 | 0.14 |
| 27 | Synthesis and degradation of ketone bodies | Acetoacetate | 9.88 × 10−1 | 0.60 |