Table 3.
List of enriched (core) genes (p value < 0.05) in each gene set corresponding to each group.
| Sr. No | Pathway | Enriched (Core) Genes |
|---|---|---|
| MMTV Group | ||
| 1 | TNF | Ccl2, Mmp3, Cxcl10, Icam1, Tnfrsf1b, Cxcl1, Fas, Tnfaip3, Ccl20, Vegfc, Creb5, Jag1, Lif, Traf5, Vcam1, Pgam5, Nod2, Ptgs2, Atf4, Il1b, Traf3, Tab1, Cxcl2, Csf1, Mlkl, NFƙBia, Pik3cb, Traf2, Ccl5, Cebpb, Rela |
| 2 | Autophagy | Prkaa2, Rragd, Rab39b, Smcr8, Uvrag, Bcl2, Ern1, Atg14, Sqstm1, Eif2s1, Irs1, Rptor, Atg2b, Ctsd, Dapk3, Igf1r, Deptor, Atg12, Pik3cb, Ppp2cb, Prkaa1, Irs2, Mapk10, Rragc, Nras, C9orf72, Akt1s1, Mapk8, Rraga |
| 3 | Type II interferon | Gvin1, Ccl2, Nlrc5, Gm4070, Pglyrp2, Ifit1bl2, Gbp6, Cxcl10, Gbp10, Ifit1, Ifi44, Ifit3b, Icam1, Gbp9, Ifit3, Isg15, Oas1a, Rsad2, Ifi211, Cgas, Cxcl9, Usp18, Gbp4, Gm4951, Stat2, Havcr2, Ifit2, Il1b |
| CTRL Group | ||
| 1 | WNT | Porcn, Fzd2, Lef1, Camk2a, Nfatc1, Wif1, Wnt1, Wnt11, Tcf7l1, Sfrp5, Rac3, Plcb4, Wnt10a, Ctnnbip1, Wnt6, Fzd4, Camk2b, Vangl2, Sfrp1, Prickle2, Ccnd1, Plcb1, Nfatc4, Wnt4, Nfatc2, Wnt10b, Nkd2, Sfrp2, Wnt5b |
| 2 | Hedgehog | Evc, Arrb1, Bmp4, Stk36, Wnt1, Wnt11, Cdon, Hhip, Wnt10a, Gli1, Wnt6, Boc, Hhatl, Hhat, Gas1, Ccnd1, Gli2, Wnt4, Bmp6, Wnt10b, Wnt5b |
| 3 | Focal adhesion | Flnc, Pip5k1c, Col6a2, Itgb1, Chad, Col6a1, Actg1, Erbb2, Pak1, Thbs2, Lamc3, Itga1, Itgb6, Mylk2, Vegfd, ln2, Pik3r3, Myl9, Mylpf, Lamc1, Lamc2, Col9a3, Mylk4, Pik3cd, Itgb3, Itga6, Col4a5, Rac3, Col9a2, Tnn, Col9a1, Cav2, Itga2, Pdgfra, Ibsp, Pdgfc, Pdgfb, Vtn, Cav1, Tnc, Pdgfrb, Ccnd1, Col4a4, Itga10, Lama3, Col1a2, Lama2, Col1a1, Col6a3, Igf1, Pdgfd, Mylk |
| 4 | Rap1 | Efna3, Pard6g, Vegfa, Pfn2, Plcb3, Magi1, Tek, Adcy1, Plcg1, Itgb1, Efna4, Actg1, Mapk12, Dock4, Vegfd, Tln2, Lpar1, Fgfr2, Pik3r3, Itgb2, Afdn, Ralgds, P2ry1, Fgfr3, Adcy8, Lat, Lpar5, Itgal Cnr1, Pik3cd, Map2k6, Itgb3, Tiam1, Angpt1, Rac3, Plcb4, Adora2b, Rgs14, Fyb, Pdgfra, Pdgfc, Adcy5, Pdgfb, Kitl, Pdgfrb, Lpar4, Rapgef4, Plcb1, Sipa1l2, Calm4, Rapgef3, Rasgrp3, Igf1, Calml3, Itgam, Pdgfd, Grin1 |
| 5 | Metabolism | Sult4a1, Btn1a1, Adam8, Selenbp1, Cyp46a1, Pygl, Slc13a4, Dcxr, Bcat1, Vim, Ggt1,Gper1, Igf2, Dpep1, Ndufa4l2, Cbr2, Pde5a, Ggt5, Gsta4,Nos1, Pdzd2, Slc38a3, Aox1, Gpd1, Galnt18, Psapl1, Sardh, Mgat5b, Ak5, Gucy1b2, Aldh1a7, Gbgt1, Gcnt3, B3gnt8, Cyp2b19, Cyp2s1, Ptgs1, Acss1, Pltp, Inpp5d, Sgpp2, Carns1, Gsta3, Fhit, Ces2g, Alas2, Ptges, Sord, Fn3k, Mgst2, Dgki, Mest, Ces2f, Pde7b, Acsbg1, Aldh1l1, Col8a1, Atp12a, Pde9a, Cyp2d11, Hao2, Chst5, Ggt6, Colgalt2, Aldoc, Rorc, Ces2e, Them5, Cyp2d34, Lipk, Arg1, Mgll, Galnt6, Alox12, Xpnpep2, Tmlhe, Alox5ap, Aldh3b2, Gxylt2, Rassf9, Acsm3, Acot11, Cyp2w1, Ddc, Slc9a4 |
| 6 | PI3-AKT-mTOR | Lamc3, Itga1, Ulk3, Itgb6, Ntf5, Myb, Vegfd, Hsp90b1, Prr5, Fgfr2, Pik3r3, Fzd2, Rxra, Cab39l, Erbb3, Creb3l2, Fgfr3, Ppp2r3a, Wnt1, Lamc1, Nr4a1, Wnt11, Lamc2, Ghr, Pkn3, Col9a3, Pik3cd, Gnb4, Gng11, Itgb3, Itga6, Bcl2l11, Col4a5, Angpt1, Cdkn1a, Col9a2, Tnn, Sgk2, Wnt10a, Col9a1, Itga2, Pdgfra, Ibsp, Wnt6, Gng7, Pdgfc, Pdgfb, Fzd4, Eif4e1b, Vtn, Prlr, Gngt2, Igf2, Syk, Tnc, Ppp2r2c, Pdgfrb, Ccnd1, Col4a4, Itga10, Chrm1, Lama3, Col1a2, Lama2, Creb3l3, Creb3l4, Wnt4, Pik3cg, Grb10, Col1a1, Pik3ap1, Wnt10b, Col6a3, Igf1, Pdgfd |
| 7 | Prolactin | Socs1, Mapk12, Thrsp, Pik3r3, Socs3, Socs2, Pik3cd, Btn1a1, Slc30a2, Pip, Prlr, Ccnd1, Cish, Cyp17a1, Elf5, Slc16a7, Slc16a4 |
| 8 | EGFR | Cav2, Reps2, Pdgfc, Prlr, Cav1, Ddit4l, Nrarp, Rps6ka5, Ceacam1, Gucy1b2, Il16, Inpp5d, Pik3cg, Grb10, Rasgrp3, Kprp, Mcf2l, Pigr, Ogn, Gprc6a, Cbs, Vipr1 |
| 9 | Hippo | Birc2, Prkcz, Crb2, Fzd1, Pard6g, Wnt7b, Llgl2, Serpine1, Actg1, Tgfb1, Smad3, Tgfbr2, Gdf5, Bmp4, Fzd2, Itgb2 Lef1, Tgfb2, Wnt1, Tead3, Wnt11, Tcf7l1, Dlg2, Ctnna3, Wnt10a, Wnt6, Fzd4, Ppp2r2c, Ccnd1, Gli2, Wnt4, Bmp6, Wnt10b, Nkd2, Dlg4, Wnt5b |
| 10 | Ras | Plcg2, Calml4, Efna5, Pik3r2, Gngt1, Fasl, Ralbp1, Fgf21, Rasgrp4, Ntrk1, Pla2g2f, Efna3, Vegfa, Foxo4, Tek, Gng2, Plcg1, Pld1, Efna4, Rasal2, Gm5741, Pak1, Ntf5, Vegfd, Fgfr2, Pik3r3, Afdn, Ralgds, Fgfr3, Lat, Pik3cd, Gnb4, Rgl2, Gng11, Tiam1, Pla1a, Angpt1, Rac3, Gab2, Pdgfra, Rasa4, Gng7, Pdgfc, Pdgfb, Pla2g2c, Gngt2, Igf2, Kitl, Pdgfrb, Calm4, Pla2g3, Rasal1, Pla2g4e, Rasgrp3, Igf1, Calml3, Pdgfd, Grin1, Rasgrp1 |
| 11 | Inflammation | Il5, Lamc1, Lamc2, Fam13a, Ltb4r1, Vtn, Gcnt1, Col1a2, Col1a1, C1qtnf3, Ptprz1, Alox5ap, Col3a1 |
| 12 | Glutathione | Gstt2, Gsta1, Gstm4, Gstm5, Gstk1, Gsto2, Mgst1, Idh2, Gstt1, Mgst3, Idh1, Gsta2, Gstm2, Ggt1, Ggt5, Gsta4, Gstm1, Gsta3, Anpep, Mgst2, Ggt6 |
| 13 | VEGF | Mapk13, Ppp3cc, Akt3, Kdr, Pla2g6, Plcg2, Nos3, Pik3r2, Pla2g2f, Vegfa, Plcg1, Mapkapk3, Mapk12, Sphk1, Pik3r3, Nfatc1, Pik3cd, Rac3, Pla2g2c, Nfatc4, Pla2g3, Nfatc2, Pik3cg, Pla2g4e |